Search results for "Fasciclin 2"

showing 3 items of 3 documents

Drosophila Full-Length Amyloid Precursor Protein is Required for Visual Working Memory and Prevents Age-Related Memory Impairment

2018

Summary The β-amyloid precursor protein (APP) plays a central role in the etiology of Alzheimer's disease (AD). However, its normal physiological functions are still unclear. APP is cleaved by various secretases whereby sequential processing by the β- and γ-secretases produces the β-amyloid peptide that is accumulating in plaques that typify AD. In addition, this produces secreted N-terminal sAPPβ fragments and the APP intracellular domain (AICD). Alternative cleavage by α-secretase results in slightly longer secreted sAPPα fragments and the identical AICD. Whereas the AICD has been connected with transcriptional regulation, sAPPα fragments have been suggested to have a neurotrophic and neu…

0301 basic medicineAgingFasciclin 2Nerve Tissue ProteinsGeneral Biochemistry Genetics and Molecular BiologyArticle03 medical and health sciences0302 clinical medicineAmyloid precursor proteinMemory impairmentAnimalsDrosophila ProteinsOlfactory memorybiologyWorking memoryfungiMembrane ProteinsLong-term potentiationCell biology030104 developmental biologyDrosophila melanogasterMemory Short-Termbiology.proteinVisual PerceptionAmyloid Precursor Protein SecretasesGeneral Agricultural and Biological SciencesAmyloid precursor protein secretase030217 neurology & neurosurgeryNeurotrophin
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Mutations in spalt cause a severe but reversible neurodegenerative phenotype in the embryonic central nervous system ofDrosophila melanogaster

2002

The gene spalt is expressed in the embryonic central nervous system of Drosophila melanogaster but its function in this tissue is still unknown. To investigate this question, we used a combination of techniques to analyse spalt mutant embryos. Electron microscopy showed that in the absence of Spalt, the central nervous system cells are separated by enlarged extracellular spaces populated by membranous material at 60% of embryonic development. Surprisingly, the central nervous system from slightly older embryos (80% of development) exhibited almost wild-type morphology. An extensive survey by laser confocal microscopy revealed that thespalt mutant central nervous system has abnormal levels o…

Central Nervous SystemHeterozygoteTime FactorsFasciclin 2Cellular differentiationCentral nervous systemLigandsCell AdhesionImage Processing Computer-AssistedIn Situ Nick-End LabelingmedicineAnimalsDrosophila ProteinsCell LineageCell adhesionMolecular BiologyCells CulturedCytoskeletonHomeodomain ProteinsNeuronsMicroscopy ConfocalMicroscopy VideobiologyCell adhesion moleculeCell DifferentiationAnatomyCadherinsbiology.organism_classificationImmunohistochemistryPhenotypeCell biologyTransplantationMicroscopy ElectronDrosophila melanogasterPhenotypemedicine.anatomical_structureMutationDrosophila melanogasterTranscription FactorsDevelopmental BiologyDevelopment
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Molecular markers for identified neuroblasts in the developing brain of Drosophila.

2003

The Drosophila brain develops from the procephalic neurogenic region of the ectoderm. About 100 neural precursor cells (neuroblasts) delaminate from this region on either side in a reproducible spatiotemporal pattern. We provide neuroblast maps from different stages of the early embryo (stages 9, 10 and 11, when the entire population of neuroblasts has formed), in which about 40 molecular markers representing the expression patterns of 34 different genes are linked to individual neuroblasts. In particular, we present a detailed description of the spatiotemporal patterns of expression in the procephalic neuroectoderm and in the neuroblast layer of the gap genes empty spiracles, hunchback, hu…

animal structuresFasciclin 2EctodermBiologyNeuroblastmedicineMorphogenesisAnimalsDrosophila ProteinsMolecular BiologyGap geneIn Situ HybridizationGeneticsHomeodomain ProteinsNeuronsNeuroectodermfungiGenes HomeoboxBrainGene Expression Regulation DevelopmentalNuclear ProteinsNeuromereCell biologyDNA-Binding Proteinsmedicine.anatomical_structureDrosophila melanogasternervous systemembryonic structuresTrans-ActivatorsHomeotic geneGanglion mother cellBiomarkersDevelopmental BiologyDevelopment (Cambridge, England)
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